CLDN19 (NM_148960) Human Recombinant Protein

• Background:

  The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO) . HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

• Synonyms:

  HOMG5

• Gene ID:

  149461

• UniProt:

  Q8N6F1

• Accession Number mRNA:

  NM_148960

• Chromosomal Location:

  1p34.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

• Field of Research:

  Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  23 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CLDN19

• Species:

  Human

• Protein ID:

  NP_683763

• Overview:

  Recombinant protein of human claudin 19 (CLDN19), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/149461

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8N6F1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_148960

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_683763