Asialoglycoprotein Receptor 2 (ASGR2) (NM_080914) Human Recombinant Protein

• Background:

  This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

• Synonyms:

  ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2

• Gene ID:

  433

• UniProt:

  P07307

• Accession Number mRNA:

  NM_080914

• Chromosomal Location:

  17p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  32.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ASGR2

• Species:

  Human

• Protein ID:

  NP_550436

• Overview:

  Recombinant protein of human asialoglycoprotein receptor 2 (ASGR2), transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/433

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07307

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_080914

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_550436