SIRT1 (NM_012238) Human Recombinant Protein

• Background:

  This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

• Synonyms:

  SIR2; SIR2alpha; SIR2L1

• Gene ID:

  23411

• UniProt:

  Q96EB6, A0A024QZQ1

• Accession Number mRNA:

  NM_012238

• Chromosomal Location:

  10q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency, Transcription Factors

• Molecular Weight:

  81.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SIRT1

• Species:

  Human

• Protein ID:

  NP_036370

• Overview:

  Recombinant protein of human sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) (SIRT1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23411

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96EB6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012238

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036370