UNC5B (NM_170744) Human Recombinant Protein

• Background:

  This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

• Synonyms:

  P53RDL1; UNC5H2

• Gene ID:

  219699

• UniProt:

  Q8IZJ1

• Accession Number mRNA:

  NM_170744

• Chromosomal Location:

  10q22.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  103.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  UNC5B

• Species:

  Human

• Protein ID:

  NP_734465

• Overview:

  Recombinant protein of human unc-5 homolog B (C. elegans) (UNC5B)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/219699

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8IZJ1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_170744

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_734465