Neurexin 1 (NRXN1) (NM_004801) Human Recombinant Protein

• Background:

  This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca (2+) -dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]

• Synonyms:

  Hs.22998; PTHSL2; SCZD17

• Gene ID:

  9378

• UniProt:

  Q9ULB1

• Accession Number mRNA:

  NM_004801

• Chromosomal Location:

  2p16.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell adhesion molecules (CAMs)

• Field of Research:

  Cell adhesion molecules (CAMs)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  158.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NRXN1

• Species:

  Human

• Protein ID:

  NP_004792

• Overview:

  Recombinant protein of human neurexin 1 (NRXN1), transcript variant alpha1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9378

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9ULB1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004801

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004792