CYLD (NM_015247) Human Recombinant Protein

• Background:

  This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Synonyms:

  BRSS; CDMT; CYLD1; CYLDI; EAC; FTDALS8; MFT; MFT1; SBS; TEM; USPL2

• Gene ID:

  1540

• UniProt:

  Q9NQC7

• Accession Number mRNA:

  NM_015247

• Chromosomal Location:

  16q12.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  RIG-I-like receptor signaling pathway

• Field of Research:

  RIG-I-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  107.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CYLD

• Species:

  Human

• Protein ID:

  NP_056062

• Overview:

  Recombinant protein of human cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1540

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NQC7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015247

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_056062