TPM1 (NM_001018007) Human Recombinant Protein

• Background:

  This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

• Synonyms:

  C15orf13; CMD1Y; CMH3; HEL-S-265; HTM-alpha; LVNC9; TMSA

• Gene ID:

  7168

• UniProt:

  P09493, A0A024R5W6

• Accession Number mRNA:

  NM_001018007

• Chromosomal Location:

  15q22.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

• Field of Research:

  Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  32.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TPM1

• Species:

  Human

• Protein ID:

  NP_001018007

• Overview:

  Purified recombinant protein of Homo sapiens tropomyosin 1 (alpha) (TPM1), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7168

• Uniprot URL:

  https://www.uniprot.org/uniprot/P09493

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001018007

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001018007