ATP1B2 (NM_001678) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

• Synonyms:

  AMOG

• Gene ID:

  482

• UniProt:

  P14415

• Accession Number mRNA:

  NM_001678

• Chromosomal Location:

  17p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cardiac muscle contraction

• Field of Research:

  Cardiac muscle contraction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  33.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ATP1B2

• Species:

  Human

• Protein ID:

  NP_001669

• Overview:

  Recombinant protein of human ATPase, Na+/K+ transporting, beta 2 polypeptide (ATP1B2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/482

• Uniprot URL:

  https://www.uniprot.org/uniprot/P14415

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001678

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001669