VPS24 (CHMP3) (NM_016079) Human Recombinant Protein

• Background:

  This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]

• Synonyms:

  CGI-149; NEDF; VPS24

• Gene ID:

  51652

• UniProt:

  Q9Y3E7

• Accession Number mRNA:

  NM_016079

• Chromosomal Location:

  2p11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis

• Field of Research:

  Endocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  24.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CHMP3

• Species:

  Human

• Protein ID:

  NP_057163

• Overview:

  Recombinant protein of human vacuolar protein sorting 24 homolog (S. cerevisiae) (VPS24), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51652

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y3E7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016079

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057163