PBR (TSPO) (NM_000714) Human Recombinant Protein

• Background:

  Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

• Synonyms:

  BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR

• Gene ID:

  706

• UniProt:

  P30536, O76068

• Accession Number mRNA:

  NM_000714

• Chromosomal Location:

  22q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Neuroactive ligand-receptor interaction

• Field of Research:

  Neuroactive ligand-receptor interaction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Activity:

  2785535929031071

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  18.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TSPO

• Species:

  Human

• Protein ID:

  NP_000705

• Overview:

  Recombinant protein of human translocator protein (18kDa) (TSPO), transcript variant PBR

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/706

• Uniprot URL:

  https://www.uniprot.org/uniprot/P30536

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000714

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000705