PML Protein (PML) (NM_033244) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL) . Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Synonyms:

  MYL; PP8675; RNF71; TRIM19

• Gene ID:

  5371

• UniProt:

  P29590

• Accession Number mRNA:

  NM_033244

• Chromosomal Location:

  15q24.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

• Field of Research:

  Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  61.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PML

• Species:

  Human

• Protein ID:

  NP_150247

• Overview:

  Recombinant protein of human promyelocytic leukemia (PML), transcript variant 5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5371

• Uniprot URL:

  https://www.uniprot.org/uniprot/P29590

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_033244

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_150247