PDE11A (NM_016953) Human Recombinant Protein

• Background:

  The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  PPNAD2

• Gene ID:

  50940

• UniProt:

  Q9HCR9

• Accession Number mRNA:

  NM_016953

• Chromosomal Location:

  2q31.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Field of Research:

  Progesterone-mediated oocyte maturation, Purine metabolism

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  104.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PDE11A

• Species:

  Human

• Protein ID:

  NP_058649

• Overview:

  Recombinant protein of human phosphodiesterase 11A (PDE11A), transcript variant 4

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/50940

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9HCR9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016953

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_058649