PKA R2 (PRKAR2A) (NM_004157) Human Recombinant Protein

• Background:

  CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER) . [provided by RefSeq, Jul 2008]

• Synonyms:

  PKR2; PRKAR2

• Gene ID:

  5576

• UniProt:

  P13861, A0A024R2W3

• Accession Number mRNA:

  NM_004157

• Chromosomal Location:

  3p21.31

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Apoptosis, Insulin signaling pathway

• Field of Research:

  Apoptosis, Insulin signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  45.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRKAR2A

• Species:

  Human

• Protein ID:

  NP_004148

• Overview:

  Recombinant protein of human protein kinase, cAMP-dependent, regulatory, type II, alpha (PRKAR2A)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5576

• Uniprot URL:

  https://www.uniprot.org/uniprot/P13861

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004157

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004148