Osteocalcin (BGLAP) (NM_199173) Human Recombinant Protein

• Background:

  This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

• Synonyms:

  BGP; OC; OCN

• Gene ID:

  632

• UniProt:

  P02818

• Accession Number mRNA:

  NM_199173

• Chromosomal Location:

  1q22

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  ES Cell Differentiation/IPS, Secreted Protein

• Molecular Weight:

  8.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BGLAP

• Species:

  Human

• Protein ID:

  NP_954642

• Overview:

  Recombinant protein of human bone gamma-carboxyglutamate (gla) protein (BGLAP)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/632

• Uniprot URL:

  https://www.uniprot.org/uniprot/P02818

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_199173

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_954642