NEDD4 (NM_006154) Human Recombinant Protein

• Background:

  This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

• Synonyms:

  NEDD4-1; RPF1

• Gene ID:

  4734

• UniProt:

  P46934

• Accession Number mRNA:

  NM_006154

• Chromosomal Location:

  15q21.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis, Ubiquitin mediated proteolysis

• Field of Research:

  Endocytosis, Ubiquitin mediated proteolysis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  104 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NEDD4

• Species:

  Human

• Protein ID:

  NP_006145

• Overview:

  Recombinant protein of human neural precursor cell expressed, developmentally down-regulated 4 (NEDD4), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4734

• Uniprot URL:

  https://www.uniprot.org/uniprot/P46934

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_006154

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_006145