CPT1A (NM_001876) Human Recombinant Protein

• Background:

  The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  CPT1; CPT1-L; L-CPT1

• Gene ID:

  1374

• UniProt:

  P50416, A0A024R5F4, Q8WZ48, B2RAQ8

• Accession Number mRNA:

  NM_001876

• Chromosomal Location:

  11q13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adipocytokine signaling pathway, Fatty acid metabolism, PPAR signaling pathway

• Field of Research:

  Adipocytokine signaling pathway, Fatty acid metabolism, PPAR signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  88.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CPT1A

• Species:

  Human

• Protein ID:

  NP_001867

• Overview:

  Recombinant protein of human carnitine palmitoyltransferase 1A (liver) (CPT1A), nuclear gene encoding mitochondrial protein, transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1374

• Uniprot URL:

  https://www.uniprot.org/uniprot/P50416

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001876

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001867