RAD52 (NM_134424) Human Recombinant Protein

• Background:

  The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

• Synonyms:

  RP11-359B12.2

• Gene ID:

  5893

• UniProt:

  P43351, Q5DR82

• Accession Number mRNA:

  NM_134424

• Chromosomal Location:

  12p13.33

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Homologous recombination

• Field of Research:

  Homologous recombination

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  46 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  RAD52

• Species:

  Human

• Protein ID:

  NP_602296

• Overview:

  Recombinant protein of human RAD52 homolog (S. cerevisiae) (RAD52)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5893

• Uniprot URL:

  https://www.uniprot.org/uniprot/P43351

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_134424

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_602296