DMAP1 (NM_019100) Human Recombinant Protein

• Background:

  This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

• Synonyms:

  DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4

• Gene ID:

  55929

• UniProt:

  Q9NPF5

• Accession Number mRNA:

  NM_019100

• Chromosomal Location:

  1p34.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  52.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DMAP1

• Species:

  Human

• Protein ID:

  NP_061973

• Overview:

  Recombinant protein of human DNA methyltransferase 1 associated protein 1 (DMAP1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55929

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NPF5

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_019100

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_061973