DAP12 (TYROBP) (NM_003332) Human Recombinant Protein

• Background:

  This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

• Synonyms:

  DAP12; KARAP; PLOSL; PLOSL1

• Gene ID:

  7305

• UniProt:

  O43914

• Accession Number mRNA:

  NM_003332

• Chromosomal Location:

  19q13.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Natural killer cell mediated cytotoxicity

• Field of Research:

  Natural killer cell mediated cytotoxicity

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  9.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TYROBP

• Species:

  Human

• Protein ID:

  NP_003323

• Overview:

  Recombinant protein of human TYRO protein tyrosine kinase binding protein (TYROBP), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/7305

• Uniprot URL:

  https://www.uniprot.org/uniprot/O43914

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003332

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003323