LEPRE1 (P3H1) (NM_022356) Human Recombinant Protein

• Background:

  This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]

• Synonyms:

  GROS1; LEPRE1; OI8

• Gene ID:

  64175

• UniProt:

  Q32P28

• Accession Number mRNA:

  NM_022356

• Chromosomal Location:

  1p34.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Secreted Protein

• Molecular Weight:

  83.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  P3H1

• Species:

  Human

• Protein ID:

  NP_071751

• Overview:

  Recombinant protein of human leucine proline-enriched proteoglycan (leprecan) 1 (LEPRE1)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64175

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q32P28

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022356

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_071751