DOCK8 (NM_203447) Human Recombinant Protein

• Background:

  This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]

• Synonyms:

  HEL-205; MRD2; ZIR8

• Gene ID:

  81704

• UniProt:

  Q8NF50

• Accession Number mRNA:

  NM_203447

• Chromosomal Location:

  9p24.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  238.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DOCK8

• Species:

  Human

• Protein ID:

  NP_982272

• Overview:

  Recombinant protein of human dedicator of cytokinesis 8 (DOCK8)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/81704

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8NF50

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_203447

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_982272