Dynamin 2 (DNM2) (NM_001005360) Human Recombinant Protein

• Background:

  Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

• Synonyms:

  CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; DYNII; LCCS5

• Gene ID:

  1785

• UniProt:

  P50570

• Accession Number mRNA:

  NM_001005360

• Chromosomal Location:

  19p13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Field of Research:

  Endocytosis, Fc gamma R-mediated phagocytosis

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Transcription Factors

• Molecular Weight:

  97.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DNM2

• Species:

  Human

• Protein ID:

  NP_001005360

• Overview:

  Recombinant protein of human dynamin 2 (DNM2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1785

• Uniprot URL:

  https://www.uniprot.org/uniprot/P50570

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001005360

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001005360