PADI2 (NM_007365) Human Recombinant Protein

• Background:

  This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

• Synonyms:

  PAD-H19; PAD2; PDI2

• Gene ID:

  11240

• UniProt:

  Q9Y2J8

• Accession Number mRNA:

  NM_007365

• Chromosomal Location:

  1p36.13

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  75.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PADI2

• Species:

  Human

• Protein ID:

  NP_031391

• Overview:

  Recombinant protein of human peptidyl arginine deiminase, type II (PADI2)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11240

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Y2J8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007365

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_031391