SCN4B (NM_174934) Human Recombinant Protein

• Background:

  The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10) . Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

• Synonyms:

  ATFB17; LQT10; Navbeta4

• Gene ID:

  6330

• UniProt:

  Q8IWT1, B0YJ93

• Accession Number mRNA:

  NM_174934

• Chromosomal Location:

  11q23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Ion Channels: Sodium, Transmembrane

• Molecular Weight:

  22 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SCN4B

• Species:

  Human

• Protein ID:

  NP_777594

• Overview:

  Recombinant protein of human sodium channel, voltage-gated, type IV, beta (SCN4B), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6330

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8IWT1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_174934

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_777594