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CORO7 (NM_024535) Human Recombinant Protein

CAT: 0882-PH33857M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PH33857M5Size:20 µg
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Background
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
Overview
Recombinant protein of human coronin 7 (CORO7)
Synonyms
0610011B16Rik; CRN7; POD1
Gene ID
79585
UniProt
P57737
Accession Number mRNA
NM_024535
Chromosomal Location
16p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
100.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CORO7
Species
Human
Protein ID
NP_078811
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/79585
Uniprot URL
https://www.uniprot.org/uniprot/P57737
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_024535
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_078811

UniProtKB · P57737

Coronin-7

CORO7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P57737
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CORO7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Crn7
EC number
—
Processing
—
Secondary accessions
B4DFD6, B4DL18, I3L416, Q17RK4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmCytoplasmic vesicleGolgi apparatusMembrane

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

Protein transportTransport

Domain

RepeatWD repeat

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