TMS1 (PYCARD) (NM_145182) Human Recombinant Protein

• Background:

  This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD) . The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  ASC; CARD5; TMS; TMS-1; TMS1

• Gene ID:

  29108

• UniProt:

  Q9ULZ3

• Accession Number mRNA:

  NM_145182

• Chromosomal Location:

  16p11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

• Field of Research:

  Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  19.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PYCARD

• Species:

  Human

• Protein ID:

  NP_660183

• Overview:

  Recombinant protein of human PYD and CARD domain containing (PYCARD), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/29108

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9ULZ3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_145182

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_660183