PIG3 (TP53I3) (NM_147184) Human Recombinant Protein

• Background:

  The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

• Synonyms:

  PIG3

• Gene ID:

  9540

• UniProt:

  Q53FA7

• Accession Number mRNA:

  NM_147184

• Chromosomal Location:

  2p23.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  P53 signaling pathway

• Field of Research:

  P53 signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  35.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TP53I3

• Species:

  Human

• Protein ID:

  NP_671713

• Overview:

  Recombinant protein of human tumor protein p53 inducible protein 3 (TP53I3), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/9540

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q53FA7

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_147184

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_671713