SFTPB (NM_198843) Human Recombinant Protein

• Background:

  This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]

• Synonyms:

  PSP-B; SFTB3; SFTP3; SMDP1; SP-B

• Gene ID:

  6439

• UniProt:

  P07988, D6W5L6

• Accession Number mRNA:

  NM_198843

• Chromosomal Location:

  2p11.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  39.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SFTPB

• Species:

  Human

• Protein ID:

  NP_942140

• Overview:

  Recombinant protein of human surfactant protein B (SFTPB), transcript variant 2

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6439

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07988

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_198843

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_942140