MPST (NM_001130517) Human Recombinant Protein

• Background:

  This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU) . Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  MST; TST2; TUM1

• Gene ID:

  4357

• UniProt:

  P25325, A0A140VJX3

• Accession Number mRNA:

  NM_001130517

• Chromosomal Location:

  22q12.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cysteine and methionine metabolism, Metabolic pathways

• Field of Research:

  Cysteine and methionine metabolism, Metabolic pathways

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  33 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MPST

• Species:

  Human

• Protein ID:

  NP_001123989

• Overview:

  Recombinant protein of human mercaptopyruvate sulfurtransferase (MPST), nuclear gene encoding mitochondrial protein, transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4357

• Uniprot URL:

  https://www.uniprot.org/uniprot/P25325

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001130517

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001123989