Neuro D4 (DPF1) (NM_001135155) Human Recombinant Protein

• Background:

  May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) . During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF) . The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  BAF45b; NEUD4; neuro-d4

• Gene ID:

  8193

• UniProt:

  Q92782

• Accession Number mRNA:

  NM_001135155

• Chromosomal Location:

  19q13.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transcription Factors

• Molecular Weight:

  46.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DPF1

• Species:

  Human

• Protein ID:

  NP_001128627

• Overview:

  Recombinant protein of human D4, zinc and double PHD fingers family 1 (DPF1), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8193

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q92782

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001135155

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001128627