ROBO2 (NM_001128929) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

• Synonyms:

  SAX3

• Gene ID:

  6092

• UniProt:

  Q9HCK4

• Accession Number mRNA:

  NM_001128929

• Chromosomal Location:

  3p12.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Axon guidance

• Field of Research:

  Axon guidance

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  152.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ROBO2

• Species:

  Human

• Protein ID:

  NP_001122401

• Overview:

  Recombinant protein of human roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/6092

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9HCK4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001128929

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001122401