PTPRB (NM_001109754) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

• Synonyms:

  HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP

• Gene ID:

  5787

• UniProt:

  P23467, Q86VA4

• Accession Number mRNA:

  NM_001109754

• Chromosomal Location:

  12q15

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Adherens junction

• Field of Research:

  Adherens junction

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  249 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTPRB

• Species:

  Human

• Protein ID:

  NP_001103224

• Overview:

  Recombinant protein of human protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 1

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5787

• Uniprot URL:

  https://www.uniprot.org/uniprot/P23467

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001109754

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001103224