EIF5A (NM_001143762) Human Recombinant Protein

• Background:

  MRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  EIF-4D; EIF-5A; EIF5A1; eIF5AI

• Gene ID:

  1984

• UniProt:

  P63241

• Accession Number mRNA:

  NM_001143762

• Chromosomal Location:

  17p13.1

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  16.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  EIF5A

• Species:

  Human

• Protein ID:

  NP_001137234

• Overview:

  Recombinant protein of human eukaryotic translation initiation factor 5A (EIF5A), transcript variant D

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1984

• Uniprot URL:

  https://www.uniprot.org/uniprot/P63241

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001143762

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001137234