CDK6 (NM_001145306) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]

• Synonyms:

  MCPH12; PLSTIRE

• Gene ID:

  1021

• UniProt:

  Q00534

• Accession Number mRNA:

  NM_001145306

• Chromosomal Location:

  7q21.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer

• Field of Research:

  Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  36.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CDK6

• Species:

  Human

• Protein ID:

  NP_001138778

• Overview:

  Purified recombinant protein of Homo sapiens cyclin-dependent kinase 6 (CDK6)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1021

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q00534

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001145306

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001138778