PRMT6 (NM_018137) Human Recombinant Protein

• Background:

  The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

• Synonyms:

  HRMT1L6

• Gene ID:

  55170

• UniProt:

  Q96LA8

• Accession Number mRNA:

  NM_018137

• Chromosomal Location:

  1p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome

• Molecular Weight:

  41.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PRMT6

• Species:

  Human

• Protein ID:

  NP_060607

• Overview:

  Recombinant protein of human protein arginine methyltransferase 6 (PRMT6) .

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55170

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q96LA8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018137

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060607