ACE2 (NM_021804) Human Recombinant Protein (Angiotensin Converting Enzyme 2)

• Background:

  The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19) . Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020]

• Synonyms:

  ACEH

• Gene ID:

  59272

• UniProt:

  Q9BYF1

• Accession Number mRNA:

  NM_021804

• Chromosomal Location:

  Xp22.2

• Expression System:

  HEK293

• Tag:

  C-FC

• Related Pathways:

  Renin-angiotensin system

• Field of Research:

  Renin-angiotensin system

• Concentration:

  >50 ug/mL as determined by Bradford protein assay method.

• Purity:

  > 90% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, 10% glycerol.

• Function:

  Druggable Genome, Secreted Protein, Transmembrane

• Molecular Weight:

  95.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ACE2

• Species:

  Human

• Protein ID:

  NP_068576

• Overview:

  Purified recombinant Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), extracellular domain of ACE spanning 1-615 residues, with C-terminal Human FC tag, expressed in HEK293.

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/59272

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BYF1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021804

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_068576