BMP4 (NM_001202) Human Recombinant Protein

• Background:

  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]

• Synonyms:

  BMP2B; BMP2B1; MCOPS6; OFC11; ZYME

• Gene ID:

  652

• UniProt:

  P12644, Q53XC5

• Accession Number mRNA:

  NM_001202

• Chromosomal Location:

  14q22.2

• Expression System:

  E. coli

• Tag:

  Tag free

• Related Pathways:

  Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway

• Field of Research:

  Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway

• Concentration:

  >50 ug/mL as determined by Bradford protein assay method.

• Endotoxin:

  < 1.0 EU per 1 μg of protein (determined by LAL method)

• Purity:

  > 85% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  10mM Sodium citrate, 10% Glycerol, pH3.50

• Function:

  Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway

• Molecular Weight:

  13.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BMP4

• Species:

  Human

• Protein ID:

  NP_001193

• Overview:

  Purified recombinant protein of Human bone morphogenetic protein 4 (BMP4), transcript variant 1, Ser293-End, tag free, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/652

• Uniprot URL:

  https://www.uniprot.org/uniprot/P12644

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001202

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001193