CARD15 (NOD2) (NM_022162) Human Recombinant Protein

• Background:

  This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs) . The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

• Synonyms:

  ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1; YAOS

• Gene ID:

  64127

• UniProt:

  Q9HC29

• Accession Number mRNA:

  NM_022162

• Chromosomal Location:

  16q12.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  NOD-like receptor signaling pathway

• Field of Research:

  NOD-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome

• Molecular Weight:

  33.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  NOD2

• Species:

  Human

• Protein ID:

  NP_071445

• Overview:

  Purified recombinant protein of Human nucleotide-binding oligomerization domain containing 2 (NOD2), Ala110-Asn409, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64127

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9HC29

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022162

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_071445