KDM6B (NM_001080424) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3) . H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

• Synonyms:

  JMJD3; NEDCFSA

• Gene ID:

  23135

• UniProt:

  O15054

• Accession Number mRNA:

  NM_001080424

• Chromosomal Location:

  17p13.1

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Molecular Weight:

  32.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  KDM6B

• Species:

  Human

• Protein ID:

  NP_001073893

• Overview:

  Purified recombinant protein of Human lysine (K) -specific demethylase 6B (KDM6B), Gln1061-Leu1350, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23135

• Uniprot URL:

  https://www.uniprot.org/uniprot/O15054

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001080424

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001073893