Laminin 5 (LAMB3) (NM_000228) Human Recombinant Protein

• Background:

  The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  AI1A; BM600-125KDA; LAM5; LAMNB1

• Gene ID:

  3914

• UniProt:

  Q13751, A0A0S2Z3R6

• Accession Number mRNA:

  NM_000228

• Chromosomal Location:

  1q32.2

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

• Field of Research:

  ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  11.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  LAMB3

• Species:

  Human

• Protein ID:

  NP_000219

• Overview:

  Purified recombinant protein of Human laminin, beta 3 (LAMB3), transcript variant 1, Tyr146-Ser249, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/3914

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13751

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000228

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000219