SIRP alpha (SIRPA) (NM_001040022) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

• Synonyms:

  BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP

• Gene ID:

  140885

• UniProt:

  P78324

• Accession Number mRNA:

  NM_001040022

• Chromosomal Location:

  20p13

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Druggable Genome, Phosphatase, Transmembrane

• Molecular Weight:

  37.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  SIRPA

• Species:

  Human

• Overview:

  Purified recombinant protein of Human signal-regulatory protein alpha (SIRPA), transcript variant 1, Glu31-Ile373, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/140885

• Uniprot URL:

  https://www.uniprot.org/uniprot/P78324

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001040022