ABCB8 (NM_007188) Human Recombinant Protein

• Background:

  This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

• Synonyms:

  EST328128; M-ABC1; MABC1; MITOSUR

• Gene ID:

  11194

• UniProt:

  Q9NUT2

• Accession Number mRNA:

  NM_007188

• Chromosomal Location:

  7q36.1

• Expression System:

  E. coli

• Tag:

  N-His ABP

• Related Pathways:

  ABC transporters

• Field of Research:

  ABC transporters

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  >80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  28.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ABCB8

• Species:

  Human

• Protein ID:

  NP_009119

• Overview:

  Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 8 (ABCB8), nuclear gene encoding mitochondrial protein, Leu5-Leu124, with N-terminal His-ABP tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/11194

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9NUT2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007188

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_009119