TMEM16A (ANO1) (NM_018043) Human Recombinant Protein

• Background:

  Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  DOG1; ORAOV2; TAOS2; TMEM16A

• Gene ID:

  55107

• UniProt:

  Q5XXA6, Q9NW72

• Accession Number mRNA:

  NM_018043

• Chromosomal Location:

  11q13.3

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  >80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Transmembrane

• Molecular Weight:

  38.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ANO1

• Species:

  Human

• Protein ID:

  NP_060513

• Overview:

  Purified recombinant protein of Human anoctamin 1, calcium activated chloride channel (ANO1), transcript variant 1, Met1-Ala333, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/55107

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q5XXA6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_018043

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_060513