CD45 (PTPRC) (NM_002838) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

• Synonyms:

  B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200

• Gene ID:

  5788

• UniProt:

  P08575

• Accession Number mRNA:

  NM_002838

• Chromosomal Location:

  1q31.3-q32.1

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway

• Field of Research:

  Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  >80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, pH8.0, 8M Urea

• Function:

  Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane

• Molecular Weight:

  20.0 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PTPRC

• Species:

  Human

• Protein ID:

  NP_002829

• Overview:

  Purified recombinant protein of Human protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1, Thr221-Gln396, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/5788

• Uniprot URL:

  https://www.uniprot.org/uniprot/P08575

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_002838

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_002829