Bloc1s2 (NM_028607) Mouse Recombinant Protein

• Background:

  Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity) . In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:16760431, PubMed:21998198) . The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:19546860) . As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2410089B13Rik; Bloc1s2a; BLOS2

• Gene ID:

  73689

• UniProt:

  Q9CWG9

• Accession Number mRNA:

  NM_028607

• Chromosomal Location:

  19 C3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  11.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bloc1s2

• Species:

  Mouse

• Protein ID:

  NP_082883

• Overview:

  Purified recombinant protein of Mouse biogenesis of lysosomal organelles complex-1, subunit 2 (Bloc1s2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/73689

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9CWG9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_028607

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_082883