Ensa (NM_001026212) Mouse Recombinant Protein

• Background:

  Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K (ATP) channel currents (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1700020C18Rik; 2610007F17Rik; AI451924

• Gene ID:

  56205

• UniProt:

  P60840

• Accession Number mRNA:

  NM_001026212

• Chromosomal Location:

  3 F2.1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  12.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ensa

• Species:

  Mouse

• Protein ID:

  NP_001021383

• Overview:

  Purified recombinant protein of Mouse endosulfine alpha (Ensa), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56205

• Uniprot URL:

  https://www.uniprot.org/uniprot/P60840

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001026212

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001021383