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Mafg (BC002092) Mouse Recombinant Protein

CAT: 0882-PM48710M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM48710M5Size:20 µg
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Background
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:16738329, PubMed:9679061) . However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:16738329, PubMed:9679061) . Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin gene expression when associated with NFE2L2 (By similarity) . May be involved in signal transduction of extracellular H (+) (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian) (cDNA clone MGC:6343 IMAGE:3488374), , with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AA545192; C630022N07Rik
Gene ID
17134
UniProt
O54790
Accession Number mRNA
BC002092
Chromosomal Location
11 84.35 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
17.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Mafg
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17134
Uniprot URL
https://www.uniprot.org/uniprot/O54790
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC002092

UniProtKB · O54790

Transcription factor MafG

MAFG_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
O54790
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mafg
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

DNA-bindingRepressor

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation