Cdkn2c (NM_007671) Mouse Recombinant Protein

• Background:

  The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]

• Synonyms:

  C77269; INK; INK4c; p1; p18; p18-INK4c; p18-INK6; p18IN; p18INK4c

• Gene ID:

  12580

• UniProt:

  Q60772, Q9D153

• Accession Number mRNA:

  NM_007671

• Chromosomal Location:

  4 51.32 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  18.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cdkn2c

• Species:

  Mouse

• Protein ID:

  NP_031697

• Overview:

  Purified recombinant protein of Mouse cyclin dependent kinase inhibitor 2C (Cdkn2c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12580

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q60772

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_007671

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_031697