Cradd (NM_009950) Mouse Recombinant Protein

• Background:

  Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  RAIDD

• Gene ID:

  12905

• UniProt:

  O88843, Q549T4

• Accession Number mRNA:

  NM_009950

• Chromosomal Location:

  10 49.26 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  22.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cradd

• Species:

  Mouse

• Protein ID:

  NP_034080

• Overview:

  Purified recombinant protein of Mouse CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12905

• Uniprot URL:

  https://www.uniprot.org/uniprot/O88843

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_009950

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034080