Fadd (NM_010175) Mouse Recombinant Protein

• Background:

  Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity) . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Mort1/FADD

• Gene ID:

  14082

• UniProt:

  Q61160

• Accession Number mRNA:

  NM_010175

• Chromosomal Location:

  7 88.85 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  23 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Fadd

• Species:

  Mouse

• Protein ID:

  NP_034305

• Overview:

  Purified recombinant protein of Mouse Fas (TNFRSF6) -associated via death domain (Fadd), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/14082

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q61160

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_010175

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034305